Registration Dossier
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EC number: 473-130-2 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EC50 147 mg/L; EC10 22.8 mg/L; NOEC 4.3 mg/L
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 147 mg/L
- EC10 or NOEC for freshwater algae:
- 22.8 mg/L
Additional information
A study was conducted to determine the acute toxicity of the test substance to the algaeDesmodesmus subspicatusaccording to EU Method C.3, in compliance with GLP.
Triplicate inocula of the algae were exposed to nominal concentrations of the test substance (0.9, 1.9, 4.3, 9.4, 20.7, 45.5 and 100 mg/L) for 72 h under static conditions. Quantification of the applied concentrations was carried out using HPLC. The measured concentrations of the test substance ranged from 99.5-103% of nominal values at 0 h, and from 101.5-109.7% of nominal values at 72 h respectively. The cell densities were measured at 24, 48 and 72 h. Inhibition of the algal population was measured as reduction in growth and growth rate, relative to control cultures grown under identical conditions.
Under the conditions of the study, the 72 h EbC10 (biomass) and ErC10 (growth rate) were determined to be 4.8 and 22.8 mg/L respectively; the EbC50 and ErC50 were determined to be 33.9 and 147 mg/L respectively; and the NOECs for biomass and growth rate were determined to be 1.9 and 4.3 mg/L respectively.
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