Registration Dossier
Registration Dossier
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EC number: 200-774-1 | CAS number: 72-19-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The calculation via ECOSAR yielded a 96 h LC50 value of 225000 mg/L.
Key value for chemical safety assessment
Additional information
No experimental test results for the substance are available.
According to REACH Regulation (Annex VIII, 9.1.3, column 2), the study on the acute toxicity to fish does not need to be done if aquatic toxicity is unlikely. Based on the available experimental toxicity data for daphnids (48 h LC50>1000 mg/L) and algae (72 h EC50>1000 mg/L) it is to be expected that the acute toxicity of L-threonine to fish will be low as well. This assumption is supported by calculation. The estimation of the acute toxicity to fish by ECOSAR v1.00 predicted a 96 h LC50=225000 mg/L for the aliphatic amine-acid structure and a 96 h LC50=1680000 mg/L for the baseline toxicity (neutral organic SAR). Based on the experimental data for daphnids and algae and the estimated acute toxicity values the need for the performance of a fish, acute toxicity test is not indicated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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