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EC number: 213-860-9
CAS number: 1038-28-4
Moderate toxic effeets, evident as a reduction in the number of
revertants, occurred in the presence of metabolic activation in strain
TA 1535 at 2500 and 5000 µg/plate and in strain TA 1537 at 1000 µg/plate
The plates incubated with the test item showed normal background
growth up to 5000 µg/plate with and without S9 mix in all strains used.
No substantial increase in revertant colony numbers of any of the
five tester strains was observed following treatment with the test
subsatnce at any concentration level, neither in the presence nor
absence of metabolic activation (S9 mix). There was also no tendency of
higher mutation rates with increasing concentrations in the range below
the generally acknowledged border of biological relevance.
Appropriate reference mutagens were used as positive controls and
showed a distinct increase of induced revertant colonies.
mutagenic potential of the test substance was evaluated in a
Salmonella/microsome test with the S. typhimurium strains TA 98, TA 100,
TA 102, TA 1535 and TA 1537 in the presence and absence of S9 mix
according to OECD TG 471. Evidence of mutagenic activity was not seen up
to the maximum recommended dose level of 5000 µg/plate. No substantial
increases in revertant colony numbers of any of the five tester strains
were observed at any dose level in the presence and absence of metabolic
activation. There was also no tendency of higher mutation rates with
increasing concentrations in the range below the generally acknowledged
border of biological relevance. Therefore, the test substance was
considered to be non-mutagenic in the Salmonella typhimurium reverse
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