Registration Dossier
Registration Dossier
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EC number: 203-104-6 | CAS number: 103-36-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- No data on the test method available.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Ethyl cinnamate
- EC Number:
- 203-104-6
- EC Name:
- Ethyl cinnamate
- Cas Number:
- 103-36-6
- Molecular formula:
- C11H12O2
- IUPAC Name:
- .
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 5.00 g/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/10
- Clinical signs:
- other: none reported
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
- Conclusions:
- The dermal LD50 is > 5000 mg/kg bw and therefore, the substance does not need to be classified according to CLP regulation.
- Executive summary:
In the current study a standard acute method was used to determine the acute dermal toxicity of the test item, however, no data are available concerning type and duration of dermal coverage. 10 animals were dosed once and observed for 14 days.
At a dose of 5.00 g/kg bw no animal died and no clinical signs were reported.
It can be concluded that the LD50 is > 5000 mg/kg bw as at this dose 0 out of 10 animals died. This is above the cutoff value of 2000 mg/kg bw of the CLP Regulation and therefore, the substance does not need to be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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