Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian germ cell study: cytogenicity / chromosome aberration
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Genotoxic effects of ethylene oxide and propylene oxide in mouse bone marrow cells
Author:
Farooqi Z, Tornqvist M, Ehrenberg L, Natarajan AT
Year:
1993
Bibliographic source:
Mutat Res 288(2):223-8

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 483 (Mammalian Spermatogonial Chromosome Aberration Test)
GLP compliance:
not specified
Type of assay:
other: bone marrow

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyloxirane
EC Number:
200-879-2
EC Name:
Methyloxirane
Cas Number:
75-56-9
Molecular formula:
C3H6O
IUPAC Name:
2-methyloxirane

Test animals

Species:
mouse

Results and discussion

Test results
Genotoxicity:
positive
Toxicity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): positive