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EC number: 942-710-1
CAS number: -
In the table, Group#1
and Group#2 were control group and treated group, respectively.
Table 1. Individual
Body Weights and Clinical Observations
Table 2. Individual
Skin Reaction on Induction Sites
Maximum score (Erythema/Edema)
-: no observation was
NA: the site could not
be observed because test article stain
Table 3. Individual
This test using the
procedures outlined in the QPS Taiwan Study Plan for T65315020-IR which
is based on the SOP for the OECD 406 (CTPS-TE00516) and OECD 406 (OECD,
1992). The results of this OECD 406 test for CJ302 show that test
reliability criteria was met.
10% and 50% (w/v) CJ302 was used for intradermal injection and
occlusively patched, respectively, to ten test guinea pigs to induce
sensitization. The water for injection was used for similar injection
and occlusively patched to five control guinea pigs. Following a
recovery period, animals received a challenge patch with 50% (w/v)
CJ302. The skin sensitization reactions were scored at approximately 24
and 48 hours after patch removal. No test article-related adverse
systemic effects were observed clinically in surviving animals during
the study period. At the end of study, body weight increase was observed
in all surviving animals. During 48 hours after challenge exposure, 90%
treated animals showed sensitization to the CJ302. Under the conditions
of this study, CJ302 caused extreme sensitization in guinea pigs.
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