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EC number: 942-710-1
CAS number: -
Acute oral tox
> 2000 mg/kg
No adverse effects.
Red / orange urine and faeces for up to 5 days post treatment.
Some skin and mucous membrane discolouration, but may be from indirect contact with urine/faeces.
Acute dermal tox
No direct testing but assessment based on similar substances indicate no adverse effects
Skin discolouration noted, persisting for the duration of observations in some cases.
Grooming may have led to oral exposure in some cases
No direct evidence of absorption.
In-vivo testing performed for non-EU regulatory processes; no significant effects
Slight discolouration of iris quickly resolved
In-vivo testing performed for non-EU regulatory processes; maximised Guinea pig study positive.
Some dermal absorption is assumed.
Tests on bacterial and mammalian cells were conducted at up to the maximum recommended concentrations with no evidence of cyto-toxicity or mutagenic potential.
The present of S-9 metabolic fraction had no impact on the findings; this does not mean that there is no metabolic process, but that any direct metabolites are similarly non-biologically active.
NOAEL 100 mg/kg/day
The NOAEL is based on maximum dose level of 1000 mg/kg/day.
Red / orange staining of urine and discoloured kidneys is evidence of absorption, distribution and excretion.
No significant biodegradation
This endpoint can indicate aerobic metabolic processes by eukaryotic cells. The absence of apparent effects suggest that there could be a low rate of metabolism, and it is probably that excretion in urine is the main route of elimination.
The substance has low toxicity with no specific target organ identified.
Lithium is known to have neurological effects at relatively high
concentrations, but at levels far greater than any accidental ingestion
of the substance.
• There is evidence of oral and dermal absorption, but also significant
faecal excretion suggesting relatively low rates of oral absorption
• The substance, or similar-coloured metabolite will be excreted in
urine and will pass through the kidneys
• Evidence from biodegradation testing and effect or S-9 activation
suggests little if any metabolic degradation.
• Lithium and sodium ions are readily absorbed by ingestion and will be
distributed in blood; as part of the natural ionic balance, excess
sodium and lithium are excreted.
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