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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Testing was conducted between 17 December 2008 and 27 January 2009.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)). Date of inspection: 21/08/2008. Date of signature: 04/03/2009
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
4,4'-bis(methoxymethyl)-1,1'-biphenyl
EC Number:
700-008-0
Cas Number:
3753-18-2
Molecular formula:
C16 H18 O2
IUPAC Name:
4,4'-bis(methoxymethyl)-1,1'-biphenyl
Constituent 2
Reference substance name:
4,4-bis(methoxymethyl)-biphenyl
IUPAC Name:
4,4-bis(methoxymethyl)-biphenyl

Results and discussion

Water solubility
Water solubility:
0.024 g/L
Temp.:
20 °C
pH:
> 5.4 - < 6.2
Details on results:
The water solubility of the test material has been determined to be 2.41 x 10-2 g/l of solution at 20.0 ± 0.5°C.

Any other information on results incl. tables

Preliminary test

The preliminary estimate of water solubility was 1.17 x 10-2 g/l.

Definitive test

The mean peak areas relating to the standard and sample solutions are shown in the following table:

Solution

MeanArea

Standard 2.03 mg/l

1.985 x 103

Standard 2.00 mg/l

1.812 x 103

Matrix Blank

0

Sample 1A

2.218 x 103

Sample 1B

2.312 x 103

Sample 2A

2.374 x 103

Sample 2B

2.351 x 103

Sample 3A

2.170 x 103

Sample 3B

2.186 x 103

The concentration (g/l) of test material in the sample solutions is shown in the following table:

Sample Number

Time Shaken at

~ 30ºC (hours)

Time Equilibrated at 20ºC (hours)

Concentration (g/l)

Solution pH

1

24

24

2.40 x 10-2

6.2

2

48

24

2.51 x 10-2

5.7

3

72

24

2.31 x 10-2

5.4

Mean concentration:2.41 x 10-2g/l at 20.0 ± 0.5ºC
Range:                                   2.31 x 10-2 to 2.51 x 10-2 g/l

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L) 24.1 mg/l
The water solubility of the test material has been determined to be 2.41 x 10-2 g/l of solution at 20.0 ± 0.5°C.
Executive summary:

The determination was carried out using the flask method, Method A6 Water Solubility of Council Regulation (EC) No 440/2008 of 30 May 2008.

The water solubility of the test material has been determined to be 2.41 x 10-2 g/l of solution at 20.0 ± 0.5°C.