Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report Date:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Gelb LD 6259
- Analytical purity: 61.3 g per 100 g
- Lot/batch No.: 0817VP01

Study design

Buffers:
- pH: 4, 7, 9
- Composition of buffer: pH 4 (Bernd Kraft, citric acid, sodium chloride, sodium hydroxide), pH 7 (Bernd Kraft, phosphate mixture), pH 9 (Bernd Kraft, boric acid, sodium hydroxide, potassium chloride), acetonitrile, dipotassium hydrogenphosphate, PIC A reagent (tetrabutylammonium hydroxide waters)

Results and discussion

Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
50 °C
Remarks on result:
other: no hydrolysis observed (<10 % within 5 days)
pH:
7
Temp.:
50 °C
Remarks on result:
other: no hydrolysis observed (<10 % within 5 days)
pH:
9
Temp.:
50 °C
Hydrolysis rate constant:
0.01 h-1
DT50:
68.3 h

Applicant's summary and conclusion