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Key value for chemical safety assessment

Additional information

 

Dichloromethane is a volatile liquid substance for which vapour inhalation is the most likely route of exposure. It is extensively studied for its repeated-dose toxicity and the available for this substance experimental data is adequate, relevant and reliable to perform the safety assessment of dichloromethane.

 

The following toxicity values were observed in studies in rodents:

 

·                   The NOAEL (oral, short-term, mice)= 333 mg/kg bw (slight vacuolation in the liver);

·                   The NOEL (oral, subchronic, rats)= 166 mg/kg bw (males)/ 209 mg/kg bw (females) (decreased body weight; effects on liver);

·                   The LOAEC (inhalation, short-term, rats) = 3500 mg/m3 (decreased body weighs, hepatic effects).

·                   The NOEC (inhalation, short-term, rats) = 880 mg/m3 (no effects on liver).

·                   The NOAEC (inhalation, subchronic, rats) = 3700 mg/m3 (decreased body weights, effects on liver, pneumonia at higher doses).

 

In conclusion, the currently available repeated-dose toxicity studies of dichloromethane via inhalation in animals report carcinogenicity as the most significant toxic effect of long-term exposure to dichloromethane.

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