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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-guidleine, non-GLP study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropane-1,3-diamine
EC Number:
251-459-0
EC Name:
N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropane-1,3-diamine
Cas Number:
33329-35-0
Molecular formula:
C15H36N4
IUPAC Name:
(3-{bis[3-(dimethylamino)propyl]amino}propyl)dimethylamine
Test material form:
gas under pressure: refrigerated liquefied gas

Test animals / tissue source

Species:
rabbit

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.1 ml of undiluted test substance administered to the eye of each animal.
Duration of treatment / exposure:
5 minute exposure and 24-hour exposure
Observation period (in vivo):
Observations at 5 mins, 24hours and 48 hours.
30 days recovery.
Number of animals or in vitro replicates:
2 groups of 8

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 5 minutes
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 5-minute exposure
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24 hours
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 5 minute and and 24 hour exposures
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 48 hours
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 5 minute and and 24 hour exposures
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 72 hours
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 24 hour exposure
Irritant / corrosive response data:
The substance is severely corrosive to the eyes of rabbits. Effects were immediate and severe, and irrevesible after a 30-day recovery period.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye)
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance is severely corrosive to the eyes of rabbits. Effects were immediate and severe, and irrevesible after a 30-day recovery period.