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Diss Factsheets
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EC number: 478-210-0 | CAS number: 69901-75-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006-10-02 to 2007-03-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study performed according to OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)) without deviations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Remarks:
- The testing facility indicated that the protocol was followed without deviation.
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Department of Health of the Government of the United Kingdom
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): VRT-126016
- Molecular formula (if other than submission substance): not applicable
- Molecular weight (if other than submission substance): not applicable
- Smiles notation (if other than submission substance): not applicable
- InChl (if other than submission substance): not applicable
- Structural formula attached as image file (if other than submission substance): not applicable
- Substance type: no data
- Physical state: white to off-white powder
- Analytical purity: 99.8 area% by High Performance Liquid Chromatography (HPLC)
- Impurities: chloride: <0.1%
- Composition of test material, percentage of components: no data
- Isomers composition: no data
- Purity test date: 2006-02-02
- Lot/batch No.: 25719
- Expiration date of the lot/batch: February 2008
- Stability under test conditions: no data
- Storage condition of test material: at room temperature
- Other: no data
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable - Radiolabelling:
- no
Study design
- Test temperature:
- 25 deg C
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Hewlett Packard 1050 Liquid Chromatograph
- Type: not applicable
- Type, material and dimension of analytical (guard) column: Hypersil CPS (25 cm x 4.6 mm i.d.)
- Detection system: UV set at 210 nm
MOBILE PHASES
- Type: Acetonitrile buffer solution (55:45 v:v) where phosphate and borate buffer solutions were employed for the pH 2.5 and pH 9 tests respectively
- Experiments with additives carried out on separate columns: not applicable
- pH: 2.5 and 9
- Solutes for dissolving test and reference substances: no, test substance was dissolved in HPLC mobile phase
DETERMINATION OF DEAD TIME
- Method: Formamide with no retenetion on the HPLC column was used to determine the deadtime of the HPLC system
REFERENCE SUBSTANCES
- Identity: Internal deadtime standard, Acetanilide, Nitrobenzene, Napthalene, 2-Methylnapththalene, Anthracene, DDT
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 0.302 ug
- Quantity of reference substances: 1-2 ug
- Intervals of calibration: no data
REPETITIONS
- Number of determinations: The test substance solution was prepared and chromatographed in duplicate, bracketed by samples of the reference mixture.
EVALUATION
- Calculation of capacity factors k': (t(r)-t0)/t0, where t(r) is the retention time of the sample or reference, and t0 is the retention time of IDS
- Calculation of retention times: true retention time = measured time - deadtime
- Determination of the log Koc value: 4.97 logk + 4.41
Batch equilibrium or other method
- Analytical monitoring:
- no
- Details on sampling:
- Not applicable
- Details on matrix:
- Not applicable
- Details on test conditions:
- Not applicable
- Computational methods:
- Not applicable
Results and discussion
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: 3.571-7.837 min
- Details of fitted regression line (log k' vs. log Koc): log Koc = 4.97 log K + 4.41
- Graph of regression line attached : no
- Average retention data for test substance: 4.25 min
Results: Batch equilibrium or other method
- Adsorption and desorption constants:
- Not applicable
- Recovery of test material:
- Not applicable
- Concentration of test substance at end of adsorption equilibration period:
- Not applicable
- Concentration of test substance at end of desorption equilibration period:
- Not applicable
- Details on results (Batch equilibrium method):
- Not applicable
- Statistics:
- Not applicable
Any other information on results incl. tables
Not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The test substance was found to have logKoc values of 2.6 and < 1.3 at pH 2.5 and pH 9 respectively.
- Executive summary:
Not applicable
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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