Registration Dossier

Administrative data

Description of key information

No dedicated studies are available for the evaluation of the irritating potential of the test substance. However, no signs of eye, skin or respiratory irritation were observed in several inhalation toxicity studies.  These include rabbits exposed by whole body for up to an hour at 100000 ppm (466000 mg/m3), rats exposed nose only for 4 hours up exposure concentrations up to 405000 (1887300 mg/m3), and rats (nose-only)  and rabbits (whole body) repeatedly exposed  to concentrations as high as 50000 ppm (233000 mg/m3). 

Key value for chemical safety assessment

Additional information

Justification for classification or non-classification

Irritation studies are no technically feasible because the substance is a gas at room temperature and ambient pressure. However, no signs of eye, skin or respiratory irritation were observed in several inhalation toxicity studies. These include rabbits exposed by whole body for up to an hour at 100000 ppm (466000 mg/m3), rats exposed nose only for 4 hours up exposure concentrations up to 405000 (1887300 mg/m3), and rats (nose-only) and rabbits (whole body) repeatedly exposed to concentrations as high as 50000 ppm (233000 mg/m3). Therefore the substance does not need to be classified for repeated exposure toxicity according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) N0. 1272/2008.