Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.

REACH

4-hydroxybenzoic acid

EC number: 202-804-9 | CAS number: 99-96-7

Life Cycle description
Uses advised against

Toxicological information

Endpoint summary

Administrative data

Key value for chemical safety assessment

Additional information

Short description of key information:
4-Hydroxybenzoic acid is expected not to cause genetic toxicity according to bacterial reverse mutation tests and chromosome aberration tests, which were both negative. There is no in vivo data available and not needed according to REACH and the observed in vitro results.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

4-HBA revealed negative results in a reverse bacterial mutation tests, in a micronucleus test and in a chromosomal aberration test. There exists no other information on mutagenic activity therefore there is no further testing necessary according to REACH standard requirements, i. e. Annex VIII 8.4., and according to regulation (EU) 1272/2008 there is no classification necessary.

Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.