Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-860-4 | CAS number: 100-52-7
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
The test substance inhibits CYP2A5 and CYP2A6 in an in vitro assay with liver microsomes (rat and human) (Rahnasto 2002). A strain difference in aldehydeoxidase activity in different strains of mice cannot be excluded (Al-Salmy 2001).
The cytotoxicity of the test substance towards Bluegill BF-2 cells was determined using inhibition of cell replication, protein synthesis, neutral red uptake, and colony formation as markers for cytotoxicity (Shen et al., 2000). Inhibition of cell replication proved to be the most sensitive with an ID50 of 3.773 mM. The results of the study indicate a direct relationship between the exposure concentration of the test substance and observed cytotoxic effects.
The cytotoxicity of the test substance is enhanced under influence of temperature as tested in normal HeLa cells and transformed cell lines (Ishida et al. 1983).
Additional information
The test substance inhibits CYP2A5 and CYP2A6 in an in vitro assay with liver microsomes (rat and human) (Rahnasto 2002). A strain difference in aldehydeoxidase activity in different strains of mice cannot be excluded (Al-Salmy 2001).
The cytotoxicity of the test substance towards Bluegill BF-2 cells was determined using inhibition of cell replication, protein synthesis, neutral red uptake, and colony formation as markers for cytotoxicity (Shen et al., 2000). Inhibition of cell replication proved to be the most sensitive with an ID50 of 3.773 mM. The results of the study indicate a direct relationship between the exposure concentration of the test substance and observed cytotoxic effects.
The cytotoxicity of the test substance is enhanced under influence of temperature as tested in normal HeLa cells and transformed cell lines (Ishida et al. 1983).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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