Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 618-882-6
CAS number: 928771-01-1
irritation potential was evaluated in a GLP-compliant guideline study
(method B5 of directive 2004/73/EC) using 3 New Zealand White rabbits.
The test sample (0.1 ml) was instilled initially into the conjunctival
sac of the right eye of one rabbit and the upper and lower eyelids held
together for approx. 1 sec. to prevent loss of the sample, then
released. The other eye served as a control. Ocular irritation was
assessed 1, 24, 48 and 72 hr post-treatment using Draize criteria. After
consideration of the responses evoked in the first animal, two
additional rabbits were treated in an identical manner. Mild
conjunctival redness, chemosis and discharge (all grade 1) were present
in all treated eyes at the 1 hr time point but were generally fully
resolved by 24 hr. The exception was the occurrence of residual mild
conjunctival redness (grade 1) in a single animal at 24 hr (fully
resolved by 48 hr). No corneal or iris effects were present in any
animal at any time point. Under the conditions of the study NExBTL
renewable diesel caused mild, fully reversible eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again