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EC number: 618-882-6
CAS number: 928771-01-1
tissue concentration of various iso-alkanes tested increased with
increasing number of carbon atoms:
C10 > C9 > C8
The tissue concentration of iso-alkane was greatest in fat and lowest in
fat >> kidney, brain, liver >> blood
Mean concentrations in fat immediately following exposure were in an
approx. range 175-900 umol/kg, with approx. 100-450 umol/kg detectable
12 hr post-exposure.
Mean concentrations in kidney, liver and brain immediately following
exposure were in an approx. range 10-70 umol/kg and generally
undetectable at 12 hr post-exposure.
Mean concentrations in blood immediately following exposure were in an
approx. range 3-7 umol/kg, and undetectable at 12 hr post-exposure.
toxicokinetic properties of C8, C9 and C10 iso-alkanes were investigated
in groups of male SD rats exposed by inhalation (100 ppm, 12 hr/d for 3
d), with the concentration of each in blood, brain, liver, kidney and
perirenal fat determined using headspace GC immediately following each
daily exposure and also 12 hr after the final exposure. The tissue
concentration of the various iso-alkanes increased with increasing
number of carbon atoms (C10 > C9 > C8), with analysed tissue
concentrations being greatest in fat and lowest in blood (fat >> kidney,
brain, liver >> blood). Detectable levels remained only in fat 12 hr
post-exposure. The results indicate uptake and distribution of inhaled
C8-C10 isoalkanes in body tissues, with rapid elimination from blood,
brain, liver and kidney but slower removal from fat.
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