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EC number: 225-716-2
CAS number: 5026-74-4
Based on the substances similarities of the physical and chemical
properties and ecotoxicological profile to
m-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline, a read across has
been proposed to fullfil toxicological endpoints where no data is
available on the target substance. Please see the relevant endpoint
summaries and read across justification document enclosed in Chapter 13.
Short term toxicity from three trophic levels (Daphnia, Fish and Algae)
is available for the misomer and for two trophic levels (Fish and Algae)
for the p-isomer substance. The results showed that L(E)C50 values to
Fish and Algae are very similar (>4.2 mg/L to 5.4 mg/L for Fish and
13 mg/L to 18 mg/L for Algae). Additionally, a chronic study on daphnia
reproduction is available on the p-isomer.
Based on the results mentioned above on physico-chemical properties and
environmental fate and given that short term toxicity on Fish and Algae
species are very similar, it is highly likely that the p-isomer
substance will show the same acute toxicity to aquatic invertebrate than
the m-isomer and that the m-isomer will have the same chronic toxicity
to Daphnia Magna in a reproduction test than the p-isomer. Consequently,
we consider scientifically justified to read-across from the m-isomer to
the p-isomer and vice versa. For further information, please refer to
the read across justification document enclosed in chapter 13.
Available Data for
In the short-term toxicity study on Carp, the LC50 after 96 hours
of treatment was 4.2 mg/L with 0% mortality at 3.2 mg/L and 100%
mortality at 5.6 mg/L.
In the short-term toxicity study on Daphnia magna, the test
substance did not induce significant acute immobilisation of Daphnia
magna at 10 mg/L after 48 hours of exposure based on analytically
confirmed nominal exposure concentrations. The 48h-EC50 was 18 mg/L
based on analytically confirmed nominal exposure concentrations (95%
confidence interval between 10 and 32 mg/L)
In the long-term toxicity study on Daphnia magnia, the exposure
to the concentrations of 1.7 mg/l and higher induced significant
inhibition of the reproductive capacity of the parental daphnids (LOEC
for reproduction). The 21d-EC50 for reproduction was 1.4 mg/l and the
21d-NOEC value for reproduction was 0.42 mg/l.
In the toxicity study to fresh water algae on Pseudokirchneriella
subcapitata, the substance reduced significantly the growth rate of
the algae species at an average exposure concentration of 26 mg/l. The
EC50 for growth rate reduction was 13 mg/l, the EC50 for yield
inhibition was 7.0 mg/l and the NOEC for growth rate reduction was 4.2
mg/l, while NOEC for yield inhibition could only be estimated to be <
Toxicity to microorganisms, investigated on Pseudomonas putida
led to no inhibition of the growth rate. The EC10 and EC50 values were >
10 000 µg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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