Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 204-661-8 | CAS number: 123-91-1
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Human study, in which basic data were given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Further studies on sensory response to certain industrial solvent vapors.
- Author:
- Silverman L, Schulte HF and First MW
- Year:
- 1 946
- Bibliographic source:
- J. Ind. Hyg. Toxicol. 28, 262-266.
Materials and methods
- Type of study / information:
- human data
- Endpoint addressed:
- eye irritation
- respiratory irritation
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- human study
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,4-dioxane
- EC Number:
- 204-661-8
- EC Name:
- 1,4-dioxane
- Cas Number:
- 123-91-1
- Molecular formula:
- C4H8O2
- IUPAC Name:
- 1,4-dioxane
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Exposed to 1,4-dioxane for 15 minutes to observe olfactory fatigue.
- Exposure assessment:
- not specified
- Details on exposure:
- TYPE OF EXPOSURE: inhalation
TYPE OF EXPOSURE MEASUREMENT: other:
EXPOSURE LEVELS: 720 and 1080 mg/m3
EXPOSURE PERIOD: 15 minutes
POSTEXPOSURE PERIOD: no data
Results and discussion
- Results:
- Twelve subjects were exposed to 1,4-dioxane for 15 minutes to observe olfactory fatigue. A concentration of 720 mg/m3 showed to be the highest concentration acceptable. At 1,080 mg/m3 irritation of eyes, nose and throat was reported, although the odour was not recognised.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
