Registration Dossier
Registration Dossier
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EC number: 203-966-3 | CAS number: 112-39-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (WS = 0.004 mg/L)
Key value for chemical safety assessment
Additional information
One study evaluating the acute toxicity of methyl palmitate (CAS No. 112-39-0) to fish species is available (Guhl, 2001). This test was conducted according to ISO Guideline 7346-1. Danio rerio was exposed to the test substance for 96 hours within a semi-static water regime, at nominal concentrations ranging from 100 to 3000 mg/L. After the exposure period, 100% mortality was observed at the highest concentrations tested (1000 and 3000 mg/L), whereas no effects were reported in any other group and therefore, the LC50 (96 h) was determined to be 550 mg/L (nominal concentrations). Nevertheless, methyl palmitate is highly insoluble in water (water solubility 0.004 mg/L) and thus, the observed effects are expected to be rather physical than associated to toxicity of the substance. Test solutions were prepared by direct addition of the substance in the vessels, followed by an ultrasonic treatment but no filtration was performed. Undissolved test material in the bottom of the test vessels and an oily film floating in the surface were observed in the test solution, probably causing the observed effects (e.g. by clogging of fish gills).
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