Registration Dossier
Registration Dossier
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EC number: 402-670-3 | CAS number: 106797-53-9 DAROCUR (R) 2959; DAROCUR 2959
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test was conducted according to OECD 401, DIrective 84/449/EEC, B.1 and compliant with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-hydroxy-4'-hydroxyethoxy-2-methylpropiophenone
- EC Number:
- 402-670-3
- EC Name:
- 2-hydroxy-4'-hydroxyethoxy-2-methylpropiophenone
- Cas Number:
- 106797-53-9
- Molecular formula:
- C12H16O4
- IUPAC Name:
- 2-hydroxy-4'-hydroxyethoxy-2-methylpropiophenone
Constituent 1
Test animals
- Species:
- other: Rat, EMD
- Strain:
- other: Wi-AF/Han (SPF)
- Sex:
- male/female
Administration / exposure
- Vehicle:
- other: Distilled watercontaining 0.25% methocel
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 1500 mg/kg bw; Number of animals: 5; Number of deaths:0
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths:0
Male: 3000 mg/kg bw; Number of animals: 5; Number of deaths:1
Female: 1500 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 2500 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 3000 mg/kg bw; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- Signs of toxicity related to dosed levels:
Dydpnea, Iocomotor disturbance, piloerection, tremor, salivation, abnomina position, increased lacrimation, tonic-clonic convulsions, hemorrhagic lacrimation, retention of faeces, blood-crousted snout.
Symotoms beginning within 15 minutes after treatment.
duration until day 5. - Gross pathology:
- Effects on organs: none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the data obtained from this study, the test substance would be assigned to GHS Category 5/unclassified.
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