Tetradecanol

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Studies in detoxication 46 The metabolism of aliphatic alcohols. The glucuronic acid conjugation of acyclic aliphatic alcohols.

Author:

Kamil I A et al

Year:

1953

Bibliographic source:

Biochem 53:129-136

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

These studies were carried out to determine the extent to which various monohydric aliphatic alcohols, including C6-C18 alcohols included in this 
category, form glucuronic acid conjugates in the rabbit. The excretion of glucuronic acids was determined daily in the urine for a week prior to administration of the test compound to establish a base line. 
Following dosing the urine was collected for 24 hours and the glucuronides extracted. The results were reported as the amount of extra glucuronic acid excreted as a % of dose.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Decan-1-ol

EC Number:

203-956-9

EC Name:

Decan-1-ol

Cas Number:

112-30-1

Molecular formula:

C10H22O

IUPAC Name:

decan-1-ol

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

Chinchilla

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Duration and frequency of treatment / exposure:

One dose

Doses / concentrations

Dose / conc.:

25 other: m-moles/rabbit

No. of animals per sex per dose / concentration:

2 animals in total (sex not specified)

Control animals:

no

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:

All the primary alcohols investigated form glucuronic acid conjugates which are excreted in the urine. However this was generally <10% of the dose. For decan-1-ol this was 3.5% glucuronic acid excreted as % of dose (average of 2 rabbits).

Any other information on results incl. tables

The extra glucuronide excreted as % of dose (average of 3 rabbits, 2 rabbits for *) was as follows:
n-hexanol 10.3%; n-heptanol 5.3%; n-octanol 9.5%; n-nonanol 4.1%; n-decanol* 3.5%; n-octadecanol* 7.6%. It was reported that absorpton of 

n-decanol and n-octadecanol was incomplete and irregular and the alcohol could be isolated in quantity from the faeces.

In addition in the case of n-decanol extra glucuronic acid appeared in the urine on the second day after dosing (whereas in most cases the excretion of extra glucuronic acid after dosing was complete within 24 hours.

No further information on other biotransformation pathways of these alcohols was provided.

Applicant's summary and conclusion

Conclusions:

Interpretation of results: no bioaccumulation potential based on study results
All the primary alcohols investigated form glucuronic acid conjugates which are excreted in the urine. However this was generally <10% of the dose.