Registration Dossier
Registration Dossier
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EC number: 202-704-5 | CAS number: 98-82-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only result reported in this compilation. No detailed documentation of test procedure and no raw data given.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List IV
- Author:
- Smyth HF, Carpenter CP, Weil CS
- Year:
- 1 951
- Bibliographic source:
- Arch Ind Hyg Occup Med 4: 119-122
- Reference Type:
- publication
- Title:
- The place of the range finding test in the industrial toxicology laboratory
- Author:
- Smyth HF, Carpenter CP
- Year:
- 1 944
- Bibliographic source:
- J Indus Hyg Toxicol 26,8: 269-274
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Six animals were given a single dose. After one week another 6 animals were given some other dose until two doses were found, differing by a factor of ten, where in one dose all animals died and in the other only some or no animals died. Post exposure period was 14 days. (see Smyth & Carpenter 1944)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cumene
- EC Number:
- 202-704-5
- EC Name:
- Cumene
- Cas Number:
- 98-82-8
- Molecular formula:
- C9H12
- IUPAC Name:
- isopropylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Cumene
- Analytical purity: Not stated
- Impurities (identity and concentrations): Not stated
- Lot/batch No.: Not given
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- Initial dose judged by previous experience (10, 1, 0.1 etc. gm/kg). Six animals were given a single dose. After one week another 6 animals were given some other dose until two doses were found, differing by a factor of ten, where in one dose all animals died and in the other only some or no animals died.
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- 2 910 mg/kg bw
- 95% CL:
- 2 550 - 3 320
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 for male albino Wistar rats was determined to be 2910 mg/kg after a single exposure and 14d post exposure observation.
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