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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Swedish report, short abstract in english and tables comprehensible, text partially translated

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl acrylate
EC Number:
203-080-7
EC Name:
2-ethylhexyl acrylate
Cas Number:
103-11-7
Molecular formula:
C11H20O2
IUPAC Name:
2-ethylhexyl acrylate
Details on test material:
- Test substance: 2-ethylhexyl acrylate
- Chemical name: 2-propenoic acid, 2-ethylhexyl ester
- Analytical Purity: 98 %

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL of the undiluted test material
Duration of treatment / exposure:
24 h
Observation period (in vivo):
72 h
Number of animals or in vitro replicates:
3
Details on study design:
Comment: rinsed after (see exposure time)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 h


Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
animal: #1 and 2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
cornea opacity score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0.33
Reversibility:
fully reversible within: 48 h
Irritation parameter:
iris score
Basis:
animal: #1, 2 and 3
Time point:
24/48/72 h
Score:
0
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
animal: #1 and 3
Time point:
24/48/72 h
Score:
0.33
Max. score:
3
Reversibility:
fully reversible within: 72 h
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
3
Irritation parameter:
chemosis score
Basis:
animal: #1 and 2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
chemosis score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0.33
Max. score:
4
Reversibility:
fully reversible within: 48 h
Irritant / corrosive response data:
Based on the results of the present study, 2-ethylhexyl acrylate was classified by the authors as non-irritating to the eye.

Any other information on results incl. tables

        Cornea		Iris		      Conjunctivae
					Erythema	Chemosis
-----------------------------------------------------------------
1 h	0/0/0		0/0/1		0/1/1		0/1/1
24 h	0/0/1		0/0/0		0/0/1		0/0/1
48 h	0/0/0		0/0/0		1/0/0		0/0/0
72 h	0/0/0		0/0/0		0/0/0		0/0/0
-----------------------------------------------------------------

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

In a test according OECD test guideline 405 and performed under GLP, 2-EHA (purity 98%) caused mild eye irritation: 0.1 ml of the substance was instilled into the eyes of 3 Albino rabbits, the following mean scores are documented for the 24, 48 and 72 observation times: cornea 0/0/0.3, iris 0/0/0.3, conjunctival redness 0.3/0/0.3, conjunctival chemosis 0/0/0.3. All signs of irritation were reversible within 3 days (Koch et al., 1985).