Registration Dossier
Registration Dossier
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EC number: 200-539-3 | CAS number: 62-53-3
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
MetHb formation observed in dogs exposed to aniline vapour was time and concentration dependent. For head-only exposed dogs the estimated threshold concentrations to cause 0.8% MetHb following a 4 and 8 h exposure were 23.6 (6.1 ppm) and 20.6 mg/m3(5.3 ppm), respectively. Whole body exposed dogs (241 mg/m3) displayed a minimum of three-fold higher in MetHb concentration when compared to head-only exposed dogs (243 mg/m3) as well as a time-delayed maximum MetHb concentration, indicating that aniline can be absorbed to a significant amount through the skin leading to a slightly protracted systemic availability.
Additional information
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