Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-125-8
CAS number: 1303-86-2
A 2-year carcinogenicity study (NTP, 1987) equivalent to OECD Guideline 451 was carried out in mice. The study showed showed that boric acid was non-oncogenic by the oral route. The NOAEL is equivalent to 201 mg B/kg bw/day (646.3 mg boric oxide/kg bw/day).
response + /
Number of animals examined
body weight gain
Overall tumour incidence:
No. of animals with neoplasms
No. of animals with benign neoplasms
No. of animals with malignant neoplasms
No. of animals with > 1 neoplasm
classification is required for boric oxide regarding carcinogenicity as
all results for boric acid were negative.
In long term
feeding studies on boric acid and disodium tetraborate decahydrate in
both rats and mice, no carcinogenic effects were observed (Weir, 1966a,
b; Weir and Fisher, 1972).
An OECD 451
equivalent study in B6C3F1 mice consisting of 50 per sex per group
treated in diet for 103 weeks with 0, 2500 or 5000 ppm boric acid showed
no evidence of carcinogenicity (NTP classification meaning no chemically
related increase in benign or malignant neoplasms).
Based on the
mouse NTP-study (1987) boric acid is not regarded carcinogenic. Although
not carried out according to modern standards, nor to GLP, the 2-year
studies in rats and dogs support this finding. While in the 2-year rat
studies, only 10 animals/sex of the control and high-dose group were
macroscopically and histologically examined, only 1-2
animals/sex/dose/time were examined in the 2-year studies in dogs, which
limits the conclusions that can be derived from these studies. However,
they were well performed and reported and are adequate to evaluate the
carcinogenicity of boric acid and sodium borates. It can be concluded
that boric acid and sodium borates are not carcinogenic and there is no
concern for carcinogenic effects in humans.
all the borates will exist as undissociated boric acid under
physiological and environmental conditions, the toxicology of all these
simple borates is similar on an equivalent boric acid basis or boron
basis. Therefore the data for boric acid and disodium tetraborate
decahydrate can be read across to the other borates for toxicological
Please also refer to the read-across
statement attached to section 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again