Registration Dossier

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards with acceptable restrictions.

Data source

Reference
Reference Type:
publication
Title:
Occupational contact dermatitis from alkanolamine borates in metalworking fluids.
Author:
Bruze, M, Hradil, E, Erikson I-L, Gruvberger B and Widstrom
Year:
1995
Bibliographic source:
Contact Dermatitis 32: 24 - 27.

Materials and methods

Type of sensitisation studied:
skin
Study type:
other: Three patients; no other data.
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Three patients were patch tested. Case No 1: Al-test, Astra Agency, Sweden with 25 µL of test agent. Case 2 & 3 ; Finn Chamber, Epicon OY, Finland with 15 µL of test agent.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Boric acid
EC Number:
233-139-2
EC Name:
Boric acid
Cas Number:
10043-35-3
Molecular formula:
H3BO3
IUPAC Name:
Boric acid
Details on test material:
- Name of test material: Boric acid tested at 3 % w/v.

Method

Type of population:
not specified
Controls:
No data
Route of administration:
dermal

Results and discussion

Results of examinations:
Not sensitising.

Applicant's summary and conclusion

Conclusions:
Boric acid tested at 3 % w/v in water showed no sensitisation in a patch test on three patients.