Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-125-8
CAS number: 1303-86-2
Boric acid was administered to male and
female rats to evaluate the potential neurotoxicity of the test
substance following a single oral gavage dose (followed by a 14-day
observation period). The test substance was administered in a vehicle of
1 % (w/v) aqueous carboxymethyl cellulose to Group 1 and 2 animals at
respective dose levels of 0 or 2000 mg/kg. Experimental endpoints
consisted of moribundity/mortality and clinical observations, body
weights and body weight gains, functional observation battery and motor
activity evaluations, post-fixation brain weights, and gross necropsy
and neurohistopathologic observations. Administration of the test
substance at 2000 mg/kg resulted in no mortality or adverse clinical
signs. Total body weight gain in the boric acid-treated male rats was
decreased 16% compared to the control group at the end of the 14-day
observation period. Functional observation battery and motor activity
evaluations did not show any evidence of neurotoxicity in either sex. No
neurohistopathology findings (gross lesions or treatment-related
microscopic findings) were observed in either sex. In conclusion, a
single oral (gavage) dose of boric acid at a level of
2000 mg/kg to male and female rats
was not neurotoxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again