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EC number: 271-846-8 | CAS number: 68609-97-2
The assessment of the likely toxicokinetic behaviour of the substance was provided to the extent that can be derived from the relevant available information at the time of the assessment. The assessment is based on the Guidance on information requirements and chemical safety assessment ChapterR.7c: Endpoint specific guidance (ECHA, November 2012).
The available information suggests that limited absorption may take place via the skin and once absorbed, the substance may potentially bind to circulatory proteins and accumulate in adipose tissues. There is no evidence suggesting how the substance is metabolised however, it is reasonable to assume excretion may takes place via biliary or more plausibly the faeces.
No bio-accumulation study in fish or any other higher organism has been performed. Epoxides are hydrolized by epoxide hydrolases generating hydroxyl terminals at the alkyl chain, which in tumare glucuronidated and excreted. Thus, no bio-accumulation is expected. In addition, a BCF = 160 has been calculated by the QSAR model of US-EPAS (Syracuse Research (2007) indicating a low bio-accumulation potential.
According to Chapter R.8 of REACH Guidance on information requirements and chemical safety assessment, it is proposed in the absence of route-specific information on the starting route, to include a default factor of 2 in the case of oral-to-inhalation extrapolation. This approach will be taken forward to DNEL derivation. In the absence of route-specific information a ratio of 1 for oral to dermal absorption, considered as worst case scenario, is provisionally suggested for the risk assessment of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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