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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Original publication in Czech; only few data could be extracted from an English abstract and from tables; However, peer reviewed data used as supporting data for HPV submission (US EPA); Scientifically acceptable.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Experimental studies of toxic effects of 1,3,5-trioxane and 1,3-dioxolane. I. Acute toxic effects
Author:
Czajkowska T, Krysiak B and Popinska E
Year:
1987
Bibliographic source:
Med Pr Vol 38 :184-190
Reference Type:
secondary source
Title:
1,3,5-TRIOXANE, CAS Number 110-88-3, USEPA HPV Challenge Program Submission
Author:
Trioxane Manufacturers Consortium Members, BASF Performance Copolymers, LLC (Formerly Ultraform Company) and Ticona
Year:
2000
Bibliographic source:
USEPA HPV Submission

Materials and methods

Principles of method if other than guideline:
The acute systemic toxicity of trioxane in rat following single administration by gavage was examined and the LD50 was determined using the Litchfield and Wilcoxon method.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Trioxane
Purity assumed to be ca. 98% (impurities reported: 2% H2O, 0.5% CH2O, 0.1% HCOOH)



Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
Designation: Wistar rats
Source: no data
Age at test initiation: no data
Body weight range at test initiation: 250 - 300 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
Not recognizable
No. of animals per sex per dose:
no data
Control animals:
not specified
Statistics:
The determination of the LD50 was based on the Litchfield and Wilcoxon method.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
8 500 mg/kg bw
95% CL:
7 320 - 9 860

Applicant's summary and conclusion