Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Animal data

In the guinea pig maximisation test, undiluted 2-phenoxyethanol was used for the challenge after intradermal and epicutaneous induction (BASF AG, 2002). The observations at 24 h and 48 h after challenge exposition revealed no reactions in any animal.
2-Phenoxyethanol was not sensitizing to the skin of guinea pigs in the maximization test.

Human data

Skin sensitisation to 2-phenoxyethanol should be considered a very rare cause of adverse reactions in humans using cosmetics and topical antiseptics containing 2-phenoxyethanol. Extensive case histories and volunteer studies exist and these consistently report very low incidence rates of the order of 1 to 3 per 1000 individuals exposed. Such rates would certainly not justify classification for this effect.


Migrated from Short description of key information:
2-Phenoxyethanol is not sensitising to guinea pig skin.

Respiratory sensitisation

Endpoint conclusion
Additional information:

Not required.

No relevant data available (literature search was performed).


Migrated from Short description of key information:
Not required.
No relevant data available (literature search was performed).

Justification for classification or non-classification

Data are conclusive but not sufficient for classification.