Formic acid

Eye irritation

Administrative data

Endpoint:

eye irritation: in vitro / ex vivo

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

Formic acid

EC Number:

200-579-1

EC Name:

Formic acid

Cas Number:

64-18-6

Molecular formula:

CH2O2

IUPAC Name:

formic acid

Results and discussion

Any other information on results incl. tables

Classification and labeling according to EU-GHS (EC 1272/2008)

 

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Index No	International Chemical Identification	EC No	CAS No	Classification		Labelling			Specific Conc. Limits, M-factors	Notes
				Hazard Class and Category Code(s)	Hazard statement Code(s)	Pictogram, Signal Word Code(s)	Hazard statement Code(s)	Suppl. Hazard statement Code(s)
607-001-00-0	formic acid … %	200-579-1	64-18-6	Skin Corr. 1A	H314	GHS05 Dgr	H314		Skin Corr. 1A; H314: C≥90 % Skin Corr. 1B; H314: 10 %≤ C < 90 % Skin Irrit. 2; H315: 2 %≤ C < 10 % Eye Irrit.2; H319: 2 %≤ C < 10 %	B

 

H314: Causes severe skin burns and eye damage

H315: Causes skin irritation

H318: Causes serious eye damage

H319: Causes serious eye irritation

 

 

 

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Index No	International Chemical Identification	EC No	CAS No	Classification	Labelling	Concentration Limits	Notes
607-001-00-0	formic acid … %	200-579-1	64-18-6	C; R35	C R: 35 S: (1/2-)23-26-45	C; R35: C≥90 % C; R34: 10 %≤C < 90 % Xi; R36/38: 2 %≤C < 10 %	B

 

 

Note B :

Some substances (acids, bases, etc.) are placed on the market in aqueous solutions at various concentrations and, therefore, these solutions

require different classification and labelling since the hazards vary at different concentrations.

 

In Part 3 entries with Note B have a general designation of the following type: ‘nitric acid … %’.In this case the supplier must state the percentage

concentration of the solution on the label. Unless otherwise stated, it is assumed that the percentage concentration is calculated on a weight/weight basis.

Applicant's summary and conclusion

Interpretation of results:

Category 1 (irreversible effects on the eye) based on GHS criteria

Remarks:

Migrated information Criteria used for interpretation of results: other: CLP Directive: EC 1272/2008 ( EU GHS)

Executive summary:

There is sufficient human data and information from animal testing indicating that formic acid is corrosive to the skin and causes eye damage.

Conclusion:

There is sufficient human data and information from animal testing to classify formic. In accordance with Annex XI, No. 1.1. of the REACH regulation,

testing is therefore scientifically not justified.