Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited information available

Data source

Reference
Reference Type:
publication
Title:
Relative effects of various chlorinated hydrocarbons on liver and kidney function in dogs
Author:
Klaassen CD, Plaa GL
Year:
1967
Bibliographic source:
Toxicol. Appl. Pharmacol. 10, 119-131

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroform
EC Number:
200-663-8
EC Name:
Chloroform
Cas Number:
67-66-3
Molecular formula:
CHCl3
IUPAC Name:
trichloromethane
Details on test material:
Mallinckrodt Batch ZJL, St. Louis, Missouri, USA

Test animals

Species:
dog

Administration / exposure

Route of administration:
intraperitoneal

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw

Applicant's summary and conclusion