Registration Dossier
Registration Dossier
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EC number: 200-663-8 | CAS number: 67-66-3
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
No valid study on the octanol-water partitioning coefficient of chloroform was found. The available data, used in a weight-of-evidence approach, indicate that the Log Pow is 1.97.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.97
- at the temperature of:
- 20 °C
Additional information
The octanol-water partitioning behaviour of chloroform was determined experimentally. The measurements of Hansch and Anderson (1967) with shaking-flask method and gas-liquid chromatography to determine the chloroform in the aqueous phase produced a value for the log P of 1.97. This value was based on five consecutive experiments. Methods for the indirect determination of the log P value and calculation methods based on quantitative structure-activity relationships (QSARs) produce log P values for chloroform ranging from 1.43 to 2.09. In conclusion, there is evidence that the log P value for chloroform is approximately 2, and it is suggested to use the experimental value of 1.97 (Hansch and Anderson 1967) for the log P of chloroform.
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