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EC number: 202-423-8 | CAS number: 95-48-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 478 (Genetic Toxicology: Rodent Dominant Lethal Test)
- GLP compliance:
- yes
- Type of assay:
- rodent dominant lethal assay
Test material
- Reference substance name:
- o-cresol
- EC Number:
- 202-423-8
- EC Name:
- o-cresol
- Cas Number:
- 95-48-7
- Molecular formula:
- C7H8O
- IUPAC Name:
- o-cresol
- Details on test material:
- Test substance: o-cresol, purity: 99.7 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMAL
- Age at study initiation: 8 weeks
- Assigned to test groups randomly: yes
- Housing: males : individually females: in groups
- Diet : ad libitum
- Water : ad libitum
- Acclimation period: 4 days
-body weights at initialtion and at termination of the assay
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25
- Humidity (%): 50
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- no further data
- Duration of treatment / exposure:
- once
- Frequency of treatment:
- once
- Post exposure period:
- 6 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 75, 250, 750 mg/kg bw in corn oil
Basis:
actual ingested
- No. of animals per sex per dose:
- 25 males per dose.
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- Triethylenemelamine
- Justification for choice of positive control(s):
- Route of administration: single i.p. injection
- Doses / concentrations: 0.3 mg/kg as a volume of 10 ml/kg,
Examinations
- Tissues and cell types examined:
- All females were examined for the number of live and dead implants within the uterine horn and whether the dead implants had occurred early or late in gestation. Live fetuses were identified as those which appeared to have a functional circulatory capacity.
- Details of tissue and slide preparation:
- no data
- Evaluation criteria:
- Statistically significant dose-related increase in the number of dominant leathals is considered as mutagenic in this system.
- Statistics:
- Chi-square test, ANOVA, Dunnett's one-tailed t test.
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Remarks:
- concentrations were chosen based on dose-range toxicity study
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- see section : "Remarks on results"
Any other information on results incl. tables
--high dose males:
Mortality: 8/25 within 6 days post dosing.
Signs of intoxication: lethary, rough haircoat, languid, tremor,
distended abdomen, squinted eyes; all surviving males recovered from
these effects within 6 days after dosing.
No effects were observed on fertility index, total implants, mean
implants per pregnant female, total live implants, total dead implants,
and body weight gain of males.
The test article was considered negative for inducing dominant lethal
mutations in germ cells of male mice under conditions of this assay.
Applicant's summary and conclusion
- Conclusions:
- The test article was considered negative for inducing dominant lethal mutations in germ cells of male mice under conditions of this assay.
- Executive summary:
The test article was considered negative for inducing dominant lethal mutations in germ cells of male mice under conditions of this assay.
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