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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Remarks:
in vivo study
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: documentation insufficient for assessment: only special aspects were examined

Data source

Reference
Title:
No information
Author:
Pereyma V.YA (1977). Vrach. Delo 5, 126-130

Materials and methods

Principles of method if other than guideline:
Method: see section "any other information on material and methods".
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol
Details on test material:
o-cresol, no data on purity

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Remarks on MMAD:
MMAD / GSD: no data
Details on inhalation exposure:
see section:"Any other information on material and methods".
Analytical verification of doses or concentrations:
not specified
Details on analytical verification of doses or concentrations:
no data
Duration of treatment / exposure:
40 d
Frequency of treatment:
4 h/d, daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.01 mg/l
Basis:

No. of animals per sex per dose:
no data
Control animals:
yes
Details on study design:
Post-exposure period: 20 d
Positive control:
no data

Examinations

Observations and examinations performed and frequency:
Concentration in the lung during exposure and post exposure.
Sacrifice and pathology:
no data
Other examinations:
Concentration in the lung during exposure and post exposure.

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Details on results:
see section "Remarks on results"

Effect levels

Dose descriptor:
conc. level:
Effect level:
0.01 mg/L air
Sex:
female

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Up to d 39 of the experiment increasing amounts of o-cresol (16,4 mg/g tissue) in lung homogenates, during recovery period o-cresol decreased (d 12: 1,1 mg/g tissue), d 16 : discovery of aminophenols)

Applicant's summary and conclusion

Executive summary:

Inhalation exposure to o-cresol leads to increasing amounts in the lung of rats which decrease during recovery period.