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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973

Materials and methods

Principles of method if other than guideline:
Acute oral toxicity study
GLP compliance:
no
Test type:
other: acute oral toxicity study

Test material

Constituent 1
Chemical structure
Reference substance name:
Di(benzothiazol-2-yl) disulphide
EC Number:
204-424-9
EC Name:
Di(benzothiazol-2-yl) disulphide
Cas Number:
120-78-5
Molecular formula:
C14H8N2S4
IUPAC Name:
di(benzothiazol-2-yl) disulphide
Details on test material:
CP 1612

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
2160, 5010, 7940 mg/kg bw
No. of animals per sex per dose:
1 to 5 animals per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 7 940 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no mortality, clinical signs: reduced appetite and activity one to three days

Any other information on results incl. tables

Mortality: no mortality occurred during the study

3160 mg/kg: male -, female (0/1), combinded (0/1)

5010 mg/kg: male (0/1), female - , combinded (0/1)

7940 mg/kg: male (0/2), female (0/3), combinded (0/5)

Clinical signs:

Reduced appetite and activity (one to three days)

Gross autopsy

Survivors (7 day): viscera appeared normal

Applicant's summary and conclusion

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