Dodecyldimethylamine

Endpoint summary

Description of key information

Full details of these endpoints are provided in the IUCLID dossier and they are considered reliable. The substance is considered "Harmful if swallowed" (Acute tox 4).
Results for the substance decyldimethylamine are presented below:
Under the conditions of the key study, the acute oral median lethal dosage (LD50) of the test material was  1200 mg/kg.

Additional information

According to the key study, the test was performed following the OECD 401, ten males rats/group were dosed orally with the test material at 0.60, 0.96, 1.54, 2.47 and 5.0 g/kg. Deaths occurred at the 4 higher dose levels generally by Day 2. The LD50, calculated from these data, was 1.22 g/kg. Lethargy, diarrhea, ataxia and piloerection, present at all dose levels, generally persisted to Day 2 and/or death. Body weight changes and necropsy findings of survivors were generally normal. One survivor had lung abnormalities and bellow normal weight gain. Spontaneous deaths had heart, lung and gastrointestinal abnormalities

According to the supporting study, the development of body weight was in the first testing week in one female animal with 1250 mg/kg-gavage was lower. At the final stage of testing the animal exceeded the initial body weight, which was measured before starting testing. In the other animals body weight development was normal. The section of animals showed dark coloured liver, reddened mucous membrane of stomach and punctual bleedings in the stomach. After finalising the testing the animals did not show macroscopic visible abnormalities.