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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable and sufficient documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Principles of method if other than guideline:
LD50 determination in dependance of the injection velocity. the examination of the acute intravenous toxicity was carried out with a 0.32 to 2.52 % aqueous solution and a constant application volume of 25 ml/kg in mice with different injection velocities between 4 and 60 seconds. symptoms of poisoning and mortality were observed during 1 hour after application of the test substance
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl alcohol
EC Number:
202-859-9
EC Name:
Benzyl alcohol
Cas Number:
100-51-6
Molecular formula:
C7H8O
IUPAC Name:
phenylmethanol
Details on test material:
benzyl alcohol pro analysi

Test animals

Species:
mouse
Strain:
other: CF1/W 68
Sex:
male
Details on test animals or test system and environmental conditions:
male CF1/W 68 mice, SPF, avarage weight 16 - 22 g; husbandry: 5 animals per cage

Administration / exposure

Route of administration:
intravenous
Vehicle:
water
Doses:
80 to 630 µl/kg (ca. 83.6 to 658.4 µg/kg)
No. of animals per sex per dose:
10 male mice per dose
Control animals:
not specified
Details on study design:
no data
Statistics:
according Fink and Hund, Arzneimittelforschung (1965), 15, 624-630

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
ca. 105 mg/kg bw
Mortality:
see remarks on results including tables and figures; dead occured during injection and up to 1 minute after injection
Clinical signs:
cyanosis, prone position, exopthalmus and gasping
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

injection velocity 4 seconds: LD50 = 105 µl/kg

injection velocity 8 seconds: LD50 = 186 µl/kg

injection velocity 15 seconds: LD50 = 242 µl/kg

injection velocity 30 seconds: LD50 = 395 µl/kg

injection velocity 60 seconds: LD50 = 514 µl/kg

injection velocity 4 seconds: LD 50 = 105 µl/kg

injection velocity 4 seconds: LD 50 = 105 µl/kg

Applicant's summary and conclusion

Executive summary:

method: LD50 determination in dependance of the injection velocity. the examination of the acute intravenous toxicity was carried out with a 0.32 to 2.52 % aqueous solution and a constant application volume of 25 ml/kg in mice with different injection velocities between 4 and 60 seconds. symptoms of poisoning and mortality were observed during 1 hour after application of the test substance

result: LD50 value depends on injection velocity; LD50 = 105 µl/kg (4 sec), LD50 = 186 µl/kg (8 sec), LD50 = 242 µl/kg (15 sec), LD50 = 395 µl/kg (4 sec), LD50 = 514 µl/kg (60 sec)

reference: Muermann (Bayer AG), 1977