Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: worker exposure
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Summary data was available for review

Data source

Reference
Reference Type:
secondary source
Title:
Skin Sensitisation Properties of Trimethoxyvinylsilane (CAS No. 2768-02-7) – Experience in Humans
Author:
Momentive
Year:
2013
Report date:
2013

Materials and methods

Type of sensitisation studied:
skin
Study type:
other: review of worker medical data
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trimethoxyvinylsilane
EC Number:
220-449-8
EC Name:
Trimethoxyvinylsilane
Cas Number:
2768-02-7
Molecular formula:
C5H12O3Si
IUPAC Name:
ethenyltrimethoxysilane

Method

Type of population:
occupational
Ethical approval:
not specified

Results and discussion

Results of examinations:
Trimethoxy(vinyl)silane is manufactured in a plants running a 5 shift process on approximately 300 days a year.

Over the course of 18 years 18 people have been in contact with the manufacturing process continuously without any indication of sensitization. An additional 24 people had been in contact with the substance during a 2 shift operational function. There is no evidence of any potential sensitization in the health files of all those individuals over the full manufacturing time.

Applicant's summary and conclusion

Conclusions:
There is no evidence of any potential sensitization in the health files of all those individuals exposed to trimethoxy(vinyl)silane over many years of manufacturing.