Registration Dossier
Registration Dossier
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EC number: 220-449-8 | CAS number: 2768-02-7
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable short-term toxicity tests results are available for freshwater fish (Oncorhynchus mykiss), invertebrates (Daphnia magna) and algae (Pseudokirchneriella subcapitata) for the registered substance, trimethoxy(vinyl)silane (CAS 2768-02-7; EC No. 220-449-8). The relevant short-term values are:
Fish: LC50 (96 h): 137 mg/L expressed in terms of concentration of the hydrolysis product, vinylsilanetriol.
Daphnia: EC50 (48 h): 121 mg/L expressed in terms of concentration of the hydrolysis product, vinylsilanetriol.
Algae: EC50 (72 h): >64 mg/L; NOEC: =64 mg/L expressed in terms of concentration of the hydrolysis product, vinylsilanetriol.
Long-term data are available with invertebrates (Daphnia magna):
21-day NOEC: 20 mg/L expressed in terms of concentration of the hydrolysis product, vinylsilanetriol.
The very rapid hydrolysis of trimethoxy(vinyl)silane (CAS 2768-02-7) (half-life 0.1 h at pH 7 and 20-25°C) means it is likely that the test organisms in each test were exposed primarily to the hydrolysis products, vinylsilanetriol (CAS 143-48-6) and methanol (CAS 67-56-1; EC No. 200-659-6).
There are no reliable microorganism toxicity data available for trimethoxy(vinyl)silane (CAS 2768-02-7), therefore good quality data for the structurally-related substance, trichloro(vinyl)silane (CAS 75-94-5; EC No. 200-917-8)), have been read across. Both substances share the same silanol hydrolysis product, vinylsilanetriol. The other hydrolysis products are methanol and hydrogen chloride / chloride salts (CAS 7647-01-0; EC No. 231-595-7) respectively.
Refer to IUCLID Section 6 endpoint summary (CSR Section 7.0) for further discussion of the approach to chemical safety assessment and justification for read-across.
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