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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
key study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 414 (Prenatal Developmental Toxicity Study)
Limit test:
no

Test material

Test animals

Species:
rat
Strain:
other:

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure (if applicable):
whole body

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
LOEC
Effect level:
3 200 ppm (nominal)
Basis for effect level:
body weight and weight gain
clinical signs
early or late resorptions
food consumption and compound intake
water consumption and compound intake
Remarks on result:
other:

Maternal abnormalities

Key result
Abnormalities:
no effects observed

Results (fetuses)

Effect levels (fetuses)

Key result
Dose descriptor:
NOAEC
Effect level:
8 000 ppm (nominal)
Based on:
test mat.
Basis for effect level:
fetal/pup body weight changes
changes in litter size and weights
Remarks on result:
other:

Fetal abnormalities

Key result
Abnormalities:
effects observed, treatment-related
Localisation:
visceral/soft tissue: hepatobiliary
visceral/soft tissue: cardiovascular

Overall developmental toxicity

Developmental effects observed:
yes
Lowest effective dose / conc.:
20 000 ppm (nominal)
Treatment related:
yes
Relation to maternal toxicity:
developmental effects as a secondary non-specific consequence of maternal toxicity effects
Dose response relationship:
yes

Applicant's summary and conclusion