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EC number: 201-070-7
CAS number: 77-93-0
This endpoint is waived due to the very low
toxicity potential of triethyl citrate.
1) From a 12-months oral study with cross over mating after 9 months in rats NOEL values for maternal toxicity and developmental toxicity were given with 50 and 250 mg/kg, respectively (Larionov AG & Cherkasova TE, 1977). [Read-across data from tributyl-O-acetylcitrate (CAS 77-90-7)]2) From a 12-months oral study with cross over mating after 9 months in mice NOEL values for maternal toxicity and developmental toxicity were given with 50 and 250 mg/kg, respectively (Larionov AG & Cherkasova TE, 1977). [Read-across data from tributyl-O-acetylcitrate (CAS 77-90-7)]
Development toxicity / teratogenicity
A Toxicological evaluation of
Acetyltributylcitrate [Larionov & Cherkasova, 1977; cited in US EPA
(2004) HPV Chemicals Challenge Program] has been carried out as follows:
Groups of rats and mice were dosed with a milk solution of ATBC via diet
at nominal doses of 50 and 250 mg/kg over 12 months. A cross-mating of
the animals was performed. In the 9th month of the study, gonads were
evaluated and the animals were evaluated for embryotoxic effects. The
dosing caused no significant effects on male sexual cells, no
embryotoxic effects and there also were no adverse effects on growth and
foetal/litter development in the offspring. The NOEL values for maternal
toxicity and developmental toxicity were given with 50 and 250 mg/kg,
respectively. It can be assumed that the same applies to triethyl
citrate (CAS 77-93-0) as it is a near analogue to the test substance
acetyl tributyl citrate.
Developmental toxicity was not
observed at dose levels up to 1000 mg/kg/day in a two-generation
reproductive toxicity study nor in a 13-week toxicity study with an in
utero exposure phase. The metabolites positively identified in the urine
of rats have been demonstrated to undergo rapid clearance from the body
and are not suspected to be developmental toxicants. Also several
long-term studies gave no indications for adverse effects on
reproductive organs. Therefore, there is no need for classification of
ATBC. As the substance 'triethyl citrate' (CAS 77-93-0) is a near
analogue to ATBC it can be considered to be also not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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