Registration Dossier

Administrative data

Description of key information

In the skin irritation study, no irritation or corrosion were observed.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for selection of skin irritation / corrosion endpoint:

Data for OS-1600 was used as an analog for 2-PO.  OS-1600 quickly hydrolyzes releasing the oximes and the silicon moieties which simultaneously cross link to other silicon atoms forming a silicone polymer.   The relevant species in the case of OS-1600 is 2-PO.  In this study, OS-1600 was not irritating to the skin of rabbits.   According to the criteria of the Globally Harmonised System and European Commission regulation 1272/2008 2-PO did not require any classification and labelling regarding skin irritation or corrosion.

Justification for classification or non-classification

Based on GHS criteria, 2 -PO is category 2.