Registration Dossier
Registration Dossier
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EC number: 200-712-3 | CAS number: 69-72-7
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
For organic carbon-water partition coefficient (Koc): 1 key study from CIT, 2002 according to OECD guideline 121.
Key value for chemical safety assessment
- Koc at 20 °C:
- 35
Additional information
The organic carbon-water partition coefficient (Koc) of salicylic acid has been determined by the HPLC method, according to the OECD Test Guideline 121 (Rhodia unpublished, CIT, 2002). As the test substance is ionisable, different mobile phases were used. The results obtained with the non buffered and the buffered mobile phase at pH6 were not usable for the estimation of the Koc value (retention time below the first reference substance and near the dead time). The buffered mobile phase at pH 3.34, which provided the non ionised form of the test substance, gave a logKoc value of 1.54 (Koc = 35). The validity criteria were considered as fulfilled and the salicylic acid is considered of high mobility in soil and sewage sludge.
The sorption behaviour of radiolabelled salicylic acid was also investigated in batch equilibrium experiments using 18 soils of various characteristics (Dubus, 2001). Although test parameters do not totally comply with the specific testing guideline OECD 106 (no preliminary test performed to determine the relevant conditions of the adsorption measurement, no adsorption kinetics have been performed) and lack of data on the test conditions (no data on the efficiency of the centrifugation conditions, no information if a blank has been run, no information if measurements were performed in duplicate), this study is considered as reliable with restrictions. The adsorption was performed during 24h at 25°C in the dark. The equilibrium was assumed to be reached within this period. No desorption was performed. At the end of the equilibration period, the soil suspensions were separated by centrifugation and the aqueous phase was analysed for measurement of radioactive content. The amount of test substance adsorbed on the soil sample was calculated as the difference between the amount of test initially present in solution and the amount remaining at the end of experiment. Sorption of Salicylic acid was largely influenced by variations in pH. The Kd values obtained for salicylic acid were between 3.6 and 397 L/kg depending of the tested soils.
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