Registration Dossier
Registration Dossier
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EC number: 203-401-0 | CAS number: 106-47-8
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Uptake, elimination, and bioconcentration of ten anilines in zebrafish (Brachidanio rerio)
- Author:
- Kalsch et al.
- Year:
- 1 991
- Bibliographic source:
- Chemosphere 22, 351-363
- Reference Type:
- review article or handbook
- Title:
- p-Chloranilin
- Author:
- Gesellschaft Deutscher Chemiker (GDCh)
- Year:
- 1 993
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA). Wissenschaftliche Verlagsgesellschaft, BUA-Stoffbericht 153
Materials and methods
- Principles of method if other than guideline:
- Bioconcentration factor (BCF) in Brachydanio rerio
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-chloroaniline
- EC Number:
- 203-401-0
- EC Name:
- 4-chloroaniline
- Cas Number:
- 106-47-8
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 4-chloroaniline
Constituent 1
- Radiolabelling:
- yes
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Route of exposure:
- aqueous
- Test type:
- static
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 24 h
Test conditions
- Nominal and measured concentrations:
- 0.20 umol/l
Results and discussion
Bioaccumulation factor
- Type:
- BCF
- Value:
- ca. 8.1
- Remarks on result:
- other: Conc.in environment / dose:0.20 umol/L
Depuration
- Depuration time (DT):
- 53 h
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
