Registration Dossier
Registration Dossier
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EC number: 216-721-0 | CAS number: 1653-19-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1972
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological characteristics of a new dichlorobutadien monomer for synthetic rubber
- Author:
- Khechumov SA, Gizhlaryan MS, Khechnumova RM
- Year:
- 1 972
- Bibliographic source:
- Toksikol Gig Neftekim Proizvod 2008-211 cited in Chem Abstr 80; 56221s (1974)
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- rats were exposed to 0.048 mg/liter of the test substance 4h/d over 3 months under static conditions using a 750 litre chamber
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2,3-dichlorobuta-1,3-diene
- EC Number:
- 216-721-0
- EC Name:
- 2,3-dichlorobuta-1,3-diene
- Cas Number:
- 1653-19-6
- Molecular formula:
- C4H4Cl2
- IUPAC Name:
- 2,3-dichlorobuta-1,3-diene
- Details on test material:
- dichlorobutadiene monomer (no further data)
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Effect levels
- Dose descriptor:
- conc. level:
- Effect level:
- 0.048 other: mg/l
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: An exposure for 4 h/day to 0.048 mg/l for 3 month produced a decrease in body weight, capability of swimming, and no. of erythrocytes, increased blood sugar, and decreased diuresis
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
