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The aerobic biodegradation of hydrocortison was studied in a modified OECD screening test according to test guideline OECD 301E. The test compound was incubated over 28 days at a concentration of 20 mg/L as DOC. Hydrocortioson was degraded to more than 90% at day 28. 60% degradation was reached approximately by day 19, 6 days after start of degradation (10% degradation). The reference compound sodium acetate was degraded to 99% on day 5, the toxicity control did not indicate any inhibiting effect. Thus, hydrocortison is ready biodegradable. The test was conducted according to GLP (see Schering report no. X089).