Registration Dossier
Registration Dossier
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EC number: 204-116-4 | CAS number: 115-95-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, low animal numbers used.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF-test according to internal SOP
Principle of the method:
Before OECD Guideline 405 was established, eye irritation was tested using an internal method (BASF test). - GLP compliance:
- no
Test material
- Reference substance name:
- Linalyl acetate
- EC Number:
- 204-116-4
- EC Name:
- Linalyl acetate
- Cas Number:
- 115-95-7
- Molecular formula:
- C12H20O2
- IUPAC Name:
- 1,5-dimethyl-1-vinylhex-4-en-1-yl acetate
- Details on test material:
- - Name of test material (as cited in study report): 3,7-dimethyl-1,6-octadien-3-yl-acetate (linalyl acetate),
- Analytical purity: 95-99%
- Impurities (identity and concentrations): dihydrolinalyl acetate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: NaCl-treated adjacent eye served as control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 µl
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- not applicable (single application; test substance was not washed out)
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2 (male)
- Details on study design:
- SCORING SYSTEM: The original BASF grading was converted into the numerical grading according to the OECD Draize system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24-48 h
- Score:
- 0.5
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24-48 h
- Score:
- 0.5
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24-48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24-48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
Any other information on results incl. tables
Application |
1st reading (1hr) |
2nd reading (24 hrs) |
3rd reading (48 hrs) |
4th reading (8 days) |
Linalyacetate animal 1 |
reddening: 2 chemosis: 1 |
reddening: 1 chemosis: 0 |
reddening:0 chemosis: 0 |
reddening:0 chemosis: 0 |
Linalyacetate animal 2 |
reddening: 1 chemosis: 1 |
reddening: 1 chemosis: 0 |
reddening:0 chemosis: 0 |
reddening:0 chemosis: 0 |
NaCl mean of two animals) |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
