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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method: BASF-test according to internal SOP
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Linalyl acetate
EC Number:
204-116-4
EC Name:
Linalyl acetate
Cas Number:
115-95-7
Molecular formula:
C12H20O2
IUPAC Name:
1,5-dimethyl-1-vinylhex-4-en-1-yl acetate
Details on test material:
- Name of test material (as cited in study report): 3,7-dimethyl-1,6-octadien-3-yl-acetate (linalyl acetate),
- Analytical purity: 95-99%
- Impurities (identity and concentrations): dihydrolinalyl acetate

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Gassner, no further data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: aquous emulsion with Traganth
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 2%, 20% and 30%-aquous solution

Doses:
200, 1600, 3200, 6400, 8000, 10000 µl/kg
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight (only initial for dosing)

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 9 000 mg/kg bw
Remarks on result:
other: Nominal value, calculated with density = 0.9 g/cm³
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 10 000 other: µl/kg bw
Mortality:
no mortality observed for the doses tested
Clinical signs:
other: immediately following administration: hyperactivity, frequent chewing, elevated breathing, piloerection, salivation, dyspnoea, apathia, agitation; following days: strubby coat, elevated breathing (6400 µl/kg); irregular breathing, crouching (8000-10000 µ
Gross pathology:
nothing abnormal detected

Any other information on results incl. tables

Dose (µl/kg bw)

Concentration (%)

Number of animals

Dead animals (day 7)

200

2

20

0/20

1600

20

20

0/20

3200

30

20

0/20

6400

30

20

0/20

8000

30

20

0/20

10000

30

20

0/20

Applicant's summary and conclusion